/* Cybergenic's instrument look: cool paper, graphite ink, hairlines, mono numerals.
   The brand red appears only in the mark: on Cybergenic it is reserved for discoveries. */
:root {
  --paper: #f4f5f7;
  --card: #ffffff;
  --ink: #15171a;
  --ink-2: #3b4048;
  --muted: #6a717c;
  --line: #d9dce1;
  --line-2: #e8eaee;
  --brand: #ff2b00;
  --brand-bg: rgba(255, 43, 0, 0.1);
  --caution: #8a5300;
  --caution-bg: #fff3dc;
  --focus: #1a5fd0;
  --sans: "Space Grotesk", ui-sans-serif, system-ui, -apple-system, "Segoe UI", sans-serif;
  --mono: "JetBrains Mono", ui-monospace, SFMono-Regular, Menlo, monospace;
}
* { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body { margin: 0; background: var(--paper); color: var(--ink); font: 15px/1.5 var(--sans); }
a { color: var(--ink); text-decoration-color: #8d949e; text-underline-offset: 2px; }
a:hover { text-decoration-color: var(--ink); }
:focus-visible { outline: 2px solid var(--focus); outline-offset: 2px; }
.wrap { max-width: 1120px; margin: 0 auto; padding: 0 20px; }

.top { border-bottom: 1px solid var(--line); background: var(--card); }
.top-inner { display: flex; align-items: center; justify-content: space-between; height: 52px; gap: 16px; }
.brand { display: inline-flex; align-items: center; gap: 8px; font-weight: 600; text-decoration: none; }
.mark { width: 24px; height: 24px; }
.mark-bg { fill: var(--brand-bg); }
.mark-fg { fill: var(--brand); }
.top-links { display: flex; gap: 18px; font-size: 14px; }
.top-links a { color: var(--ink-2); text-decoration: none; }
.top-links a:hover { color: var(--ink); text-decoration: underline; }

.intro { padding: 28px 0 8px; }
h1 { font-size: 28px; line-height: 1.2; margin: 0 0 8px; font-weight: 600; letter-spacing: -0.01em; }
.lede { max-width: 760px; margin: 0 0 8px; color: var(--ink-2); font-size: 16px; }
.source { margin: 0; color: var(--muted); font-size: 13px; }
.source .num { font-family: var(--mono); }

.query { display: grid; grid-template-columns: 1fr 1fr 1.2fr auto auto; gap: 12px; align-items: end; margin: 20px 0 10px; padding: 14px; background: var(--card); border: 1px solid var(--line); border-radius: 6px; }
.field { display: flex; flex-direction: column; gap: 4px; min-width: 0; }
.field label { font-size: 12px; color: var(--muted); text-transform: uppercase; letter-spacing: 0.05em; }
.field .opt { text-transform: none; letter-spacing: 0; }
.field input, .field select { font: 15px var(--sans); height: 38px; padding: 0 10px; border: 1px solid var(--line); border-radius: 4px; background: var(--card); color: var(--ink); width: 100%; }
.field input[type="checkbox"] { width: 16px; height: 16px; padding: 0; margin: 0; accent-color: var(--ink); }
.field input:not([type="checkbox"]) { font-family: var(--mono); font-size: 14px; text-transform: uppercase; }
.field input::placeholder { text-transform: none; color: #6f7680; }
.field-check { justify-content: center; height: 38px; }
.field-check .check { text-transform: none; letter-spacing: 0; font-size: 13px; color: var(--ink-2); display: flex; gap: 6px; align-items: center; cursor: pointer; white-space: nowrap; }
.field-buttons { flex-direction: row; gap: 8px; }
button { font: 500 14px var(--sans); height: 38px; padding: 0 16px; border-radius: 4px; border: 1px solid var(--ink); background: var(--ink); color: #fff; cursor: pointer; }
button.ghost { background: transparent; color: var(--ink); border-color: var(--line); }
button:disabled { opacity: 0.45; cursor: default; }

.examples[hidden] { display: none; }
.examples { display: flex; flex-wrap: wrap; gap: 8px; align-items: center; margin: 0 0 14px; font-size: 13px; color: var(--muted); }
.examples button { height: 28px; padding: 0 10px; font-size: 13px; background: var(--card); color: var(--ink-2); border-color: var(--line); font-weight: 400; }
.examples button:hover { border-color: var(--ink-2); color: var(--ink); }

.status { font-size: 14px; color: var(--muted); margin: 8px 0; min-height: 21px; }
.status.error { color: #8f1d12; }

.result { margin: 6px 0 24px; }
.panel { background: var(--card); border: 1px solid var(--line); border-radius: 6px; margin: 0 0 16px; }
.panel-head { padding: 14px 16px 12px; border-bottom: 1px solid var(--line-2); }
.panel-head h2 { margin: 0 0 4px; font-size: 19px; font-weight: 600; }
.panel-head p { margin: 0; color: var(--ink-2); max-width: 900px; }
.panel-head .links { margin-top: 6px; font-size: 13px; color: var(--muted); display: flex; flex-wrap: wrap; gap: 14px; }
.panel-note { padding: 10px 16px; font-size: 13px; color: var(--muted); border-top: 1px solid var(--line-2); }
.empty { padding: 18px 16px; color: var(--ink-2); }

.table-scroll { overflow-x: auto; }
.table-scroll.scrolls::before { content: "Scroll sideways for every column"; display: block; padding: 6px 16px; font-size: 12px; color: var(--muted); border-bottom: 1px solid var(--line-2); position: sticky; left: 0; }
table { width: 100%; border-collapse: collapse; font-size: 13.5px; }
th, td { padding: 8px 12px; text-align: left; border-bottom: 1px solid var(--line-2); vertical-align: top; }
th { font-size: 11.5px; font-weight: 500; color: var(--muted); text-transform: uppercase; letter-spacing: 0.05em; white-space: nowrap; background: #fafbfc; }
td.n, th.n { text-align: right; }
td.n, .mono { font-family: var(--mono); font-size: 12.5px; font-variant-numeric: tabular-nums; }
td.n { white-space: nowrap; }
td.cohort { min-width: 220px; }
tr:last-child td { border-bottom: 0; }
tbody tr:hover td { background: #fafbfc; }
.gene { font-family: var(--mono); font-weight: 500; white-space: nowrap; }
.linkish { background: none; border: 0; padding: 0; height: auto; color: var(--ink); font: inherit; text-align: left; text-decoration: underline; text-decoration-color: #8d949e; text-underline-offset: 2px; cursor: pointer; }
.linkish:hover { text-decoration-color: var(--ink); }
.sub { color: var(--muted); font-size: 12.5px; }
.out { white-space: nowrap; }
.dot { display: inline-block; width: 9px; height: 9px; border-radius: 50%; margin-right: 6px; vertical-align: 0; border: 1.5px solid var(--ink); }
.dot.co { background: var(--ink); }
.dot.ex { background: transparent; }
.dot.none { border-color: #b9bec6; background: transparent; border-style: dotted; }
.tag { display: inline-block; font-size: 11.5px; padding: 1px 6px; border: 1px solid var(--line); border-radius: 3px; color: var(--ink-2); margin: 2px 4px 0 0; white-space: nowrap; }
.tag.kept { border-color: var(--ink); color: var(--ink); }
.tag.caution { background: var(--caution-bg); border-color: #f0d6a6; color: var(--caution); }
.arrow { text-decoration: none; color: var(--muted); font-size: 12px; margin-left: 4px; white-space: nowrap; }
.arrow:hover { color: var(--ink); }

.care { margin: 0 0 28px; background: var(--card); border: 1px solid var(--line); border-radius: 6px; padding: 12px 16px; }
.care summary { cursor: pointer; font-weight: 500; }
.care ul { margin: 10px 0 2px; padding-left: 20px; color: var(--ink-2); font-size: 14px; }
.care li { margin: 0 0 6px; }

.foot { border-top: 1px solid var(--line); background: var(--card); font-size: 13px; color: var(--muted); }
.foot p { margin: 14px 0; max-width: 900px; }
.foot a { color: var(--ink-2); }

@media (max-width: 860px) {
  .query { grid-template-columns: 1fr 1fr; }
  .field-check, .field-buttons { grid-column: span 2; }
  .field-check { height: auto; }
  h1 { font-size: 23px; }
  .top-links { gap: 12px; font-size: 13px; }
}
@media (max-width: 520px) {
  .query { grid-template-columns: 1fr; }
  .field-check, .field-buttons { grid-column: auto; }
  .top-links a:nth-child(3) { display: none; }
}
@media (prefers-reduced-motion: reduce) { * { scroll-behavior: auto !important; } }